Cytotoxicity andIn VitroAntileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
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منابع مشابه
Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance. Lapachol [2-hydroxy-3-(3'-methyl-2-butenyl)-1,4-naphthoquinone] displays a wide range of antimicrobial properties against many pathogens. In this study, using the classic microscopic in vitro model, we have analyzed the effects of a series of lapachol and chlorides com...
متن کاملAntimony(V) and bismuth(V) complexes of lapachol: synthesis, crystal structure and cytotoxic activity.
Antimony(V) and bismuth(V) complexes of lapachol have been synthesized by the reaction of Ph₃SbCl₂ or Ph₃BiCl₂ with lapachol (Lp) and characterized by several physicochemical techniques such as IR, and NMR spectroscopy and X-ray crystallography. The compounds contain six-coordinated antimony and bismuth atoms. The antimony(V) complex is a monomeric derivative, (Lp)(Ph₃Sb)OH, and the bismuth(V) ...
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15 صفحه اولAmphiphilic Antimony(V) Complexes for Oral Treatment of Visceral Leishmaniasis.
The need for daily parenteral administration is an important limitation in the clinical use of pentavalent antimonial drugs against leishmaniasis. In this study, amphiphilic antimony(V) complexes were prepared from alkylmethylglucamides (L8 and L10, with carbon chain lengths of 8 and 10, respectively), and their potential for the oral treatment of visceral leishmaniasis (VL) was evaluated. Comp...
متن کاملElectronic Spectra and Photochemistry of Tin(II), Lead(II), Antimony(III), and Bismuth(III) Bromide Complexes in Solution
The electronic spectra o f bromo complexes o f main group metal ions with an s2 electronic configuration (SnBr3~, PbBr3~, PbBr42_, SbBr4~, SbBr63~, BiBr4~, BiBr63~) in acetonitrile show long-wavelength absorption bands which are assigned to metal-centered sp transitions. Com pared to the corresponding chloro complexes the sp bands o f the bromo complexes appear at longer wavelength due to sp/L...
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ژورنال
عنوان ژورنال: Bioinorganic Chemistry and Applications
سال: 2013
ISSN: 1565-3633,1687-479X
DOI: 10.1155/2013/961783